Using Animal Models In Biomedical Research: A Primer For The InvestigatorAnimal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof of principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and required of all biomedical researchers. However, while both