Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery - Paperbackby Mahdi Karimi (Author), Parham Sahandi Zangabad (Author), Amir Ghasemi (Author) The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble